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TB remains a major cause of disability and death worldwide as an estimated 8.6 million people fell ill with TB and 1.3 million people died from the disease in 2012, according to the World Health Organization. Although TB is curable, adherence to therapy is difficult as treatment requires taking antibiotic drugs for at least six months and sometimes up to two years. Poor adherence to medication and other factors have resulted in drug-resistant strains, and currently no effective TB vaccine exists. To address the need for alternative interventions, scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, demonstrated proof-of-concept for a host-directed strategy to treat tuberculosis. They found that interleukin-1, a type of protein that regulates the body's immune response to infection, can help protect the body from TB infection. Their studies in cells and in mice and human patients infected with TB bacteria demonstrated that interleukin-1 induces a mediator, prostaglandin E2 (PGE2), that limits the production of type-I interferons, which are associated with increased TB disease severity. The scientists found that host-directed immunotherapy using PGE2 and zileuton, a clinically-approved drug typically used to treat asthma, prevented death in TB-infected mice. This strategy could be of particular benefit to people infected with drug-resistant TB strains who have limited options for effective antibiotics because the treatment increased bacterial control and limited disease even in the absence of TB chemotherapy. In principle, this approach is compatible with standard antibiotic regimens, according to the authors. In future studies, NIAID scientists will test adjunct host-directed therapies in TB-infected individuals. ARTICLE: KD Mayer-Barber et al. Host-directed therapy of tuberculosis based on interleukin-1 - type I interferon crosstalk. Nature. DOI: 10.1038/nature13489 (2014). WHO: NIAID Director Anthony S. Fauci, M.D., is available to comment on this research. Katrin Mayer-Barber, Ph.D., of NIAID's Laboratory of Parasitic Diseases and Alan Sher, Ph.D., chief of the laboratory, are co-authors on the letter and are also available for comment.
For the original version including any supplementary images or video, visit http://www.news-medical.net/news/20140628/Host-directed-therapy-A-new-type-of-TB-treatment.aspx
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No exploration has been performed at Bunawan. Pierce sample recuperation Method of recording and also examining core as well as chip example rehabilitations and also results evaluated. Actions taken to make the most of sample recovery and also ensure depictive nature of the examples. Whether a partnership exists in between sample recovery and quality and whether example predisposition may have taken place because of preferential loss/gain of fine/coarse product. No exploration has actually been performed at Bunawan. Logging Whether core as well as chip samples have been geologically as well as geotechnically logged to a degree of specific to assist appropriate Mineral Source estimate, mining studies as well as metallurgical researches. Whether logging is qualitative or quantitative in attributes. Core(or costean, network, etc. )photography. The total length as well as percentage of the pertinent crossways logged. No drilling has actually been conducted at Bunawan. Sub-sampling methods and example preparation If core, whether cut or sawn and also whether quarter, half or all core taken. If non-core, whether riffled, tube sampled, rotary split, etc as well as whether tried out moist or completely dry. For all example types, the nature, quality and appropriateness of the sample preparation technique. Quality assurance procedures adopted for all sub-sampling phases to optimize representivity of examples. Actions taken to make sure that the sampling is agent of the in situ product collected, consisting of for example results for area duplicate/second-half sampling. Whether example dimensions are proper to the grain dimension of the product being tried out. No exploration has been carried out at Bunawan. Dirt samples were gathered from the soil C perspective usually at roughly 40 to 50cm deepness below surface and also submitted to the Intertek Research laboratory in Manila where the minus 40 mesh(425m)portion was sieved for analysis. A quartz clean was conducted prior to each example during sample preparation and also a brand-new pot was used for each and every fire assay in order to reduce any kind of prospective contamination. Twenty area duplicates were included in the soil sample program. Duplicates were addressed likewise and also sieved at the laboratory rather than in the industry. Twenty area duplicate samples were included in the soil sample program. Duplicates were gathered from separate however surrounding pits. Big examples( approx. 5Kg) were accumulated and also sieved. The preliminary example dimension is taken into consideration proper. Quality of assay information and laboratory tests The attributes, quality and also appropriateness of the assaying and also research laboratory procedures utilized and whether the strategy is taken into consideration partial or total. For geophysical devices, spectrometers, handheld XRF instruments, etc, the specifications made use of in identifying the analysis including tool make as well as design, reading times, calibrations factors used and their derivation, etc. (br) For the original variation including any sort of additional images or video, browse through (a href=' http://finance.yahoo.com/news/rtg-announces-granting-bunawan-exploration-130000808.html' rel ='nofollow ') http://finance.yahoo.com/news/rtg-announces-granting-bunawan-exploration-130000808.html
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(PRWEB) August 08, 2014 The report "" DR as a Solution Market [RaaS; Cloud DR; Catastrophe Rehabilitation as a Support service; Business Connection as a Solution; Cloud DR] - Worldwide Forecasts and Analysis - 2018"" defines and segments the global cloud based DR market with evaluation and forecasting of global earnings. It also recognizes vehicle drivers and restraints for the RaaS market, with ideas on trends, chances and obstacles. In addition to this, the report also supplies a cloud based DR ecological community, business spending plan and RaaS fostering analysis, and worth chain analysis. Browse 134 market information tables and 71 numbers spread out via 222 web pages and thorough TOC on DR as a Solution Market [RaaS; Cloud DR; Catastrophe Recuperation as a Service; Company Continuity as a Support service; Cloud DR] - Worldwide Forecasts and Evaluation - 2018. Early buyers will obtain 10 % customization on records. Investment copy of report today - http://www.marketsandmarkets.com/Purchase/purchase_report1.asp?id=962. The global DRaaS and company connection market is determined to expand to $5.77 billion by 2018. This stands for a compounded yearly growth price (CAGR) of 55.2 % 2018. Execution of RaaS in organizations is anticipated to boost in order to guarantee business continuity and to lessen future investments on IT infrastructure. The RaaS and company continuity markets, along with each of their sub-segments are additional bifurcated by region. The bifurcation includes North The united state (NA), Europe, Asia-Pacific; consisting of Japan (APAC), Latin America (LA), Middle East and Africa (MEA). Over the following five years, Asia-Pacific (APAC), Europe and North The united state is anticipated to experience increased market traction, by increasing recognition on cloud based technologies driving this market. MarketsandMarkets has segmented the global Recovery-as-a-Service market based upon kinds, storage space, suppliers, verticals and organization size. The RaaS kinds segment includes self calamity recuperation version, equipment to cloud catastrophe recuperation, cloud to shadow calamity recovery model; whilst the storage space kinds have been fractional based on 1 TB and below, 1 TB - 10 TB, 10 TB and above. The RaaS service providers segment consists of calamity recuperation company, cloud provider, Telecommunications and interactions company (CSP), innovation companions and vendors, and others. The upright segment comprises of banking, monetary services and insurance policy (BFSI), E-commerce and web, academic community and government, production, healthcare and others. Company size comprises of small office / home workplace (SOHO), little and medium companies (SMB) in addition to ventures. The major pressures driving the marketplace are aspects such as affordable, high level of automation, dynamism, 24 \* 7 support, protected storage and backup, area freedom, virtualization, very easy deployability, recovery, administration and control, along with high utility based Business Continuity. At the exact same time, consumers are worried about protection and personal privacy in terms of cloud based DR application. Catastrophe recuperation and company connection has actually been in the market because the late 2000s. However, the buzz amongst organizations about DR and business continuity is merely a couple of years old. DRaaS is anticipated to change IT facilities concern with budget-friendly and reliable solutions. The report also profiles major market players in the cloud based DR area, which includes VMware, EVault, Geminare, NTT America, Windstream Communications, CA innovations, Microsoft, IBM, Carpathia Hosting, CommVault, HP, Doyenz, FusionStorm, Rackspace, Amazon web solutions, nScaled, SunGard, Datto, OpSource and Zerto amongst others. Demand for modification at http://www.marketsandmarkets.com/requestCustomization.asp?id=962. Browse Related Record Middle East Cyber Security Market by Technologies (IAM, DLP, UTM, IDS/IPS, Firewall, Threat & & Conformity Administration, Antivirus, SVM/SIEM, Catastrophe Recuperation, DDOS Mitigation, File encryption, Web Filtering) & & by Solutions - Market Projections and Analysis (2014-2019) http://www.marketsandmarkets.com/Market-Reports/mass-notification-market-1248.html Regarding MarketsandMarkets MarketsandMarkets is a worldwide marketing research and seeking advice from firm based in the U.S. We publish tactically analyzed market research reports and act as a business knowledge team to Ton of money 500 firms across the world. MarketsandMarkets also gives multi-client records, company profiles, databases, and personalized study solutions. MarketsandMarkets covers thirteen sector verticals; consisting of advanced products, automotives and transportation, financial and economic support services, biotechnology, chemicals, durable goods, telecommunications and IT, energy and power, meals and beverages, industrial automation, clinical gadgets, pharmaceuticals, semiconductor and electronic devices, aerospace & & protection. We at MarketsandMarkets are inspired to help our clients increase by supplying proper company idea with our huge market intelligence database. Contact: ) For the original version consisting of any sort of additional pictures or electronic, browse through ) http://www.prweb.com/releases/recovery-as-a-service/market/prweb12079051.htm
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A link has been sent. Done Alamo Group Announces 2014 Second Quarter Results Alamo Group Inc. 1 hour ago 0 shares Content preferences Done SEGUIN, Texas, Aug. 6, 2014 /PRNewswire/ --Alamo Group Inc. ( ALG ) today reported results for the second quarter ended June 30, 2014. Highlights for the Quarter Record net sales for the quarter of $206.3 million Company finishes quarter with record backlog Industrial Division continued to benefit from increased core products demand Earnings constrained by weakening agricultural market and acquisition-related expenses Results include Specialized business units acquired in May 2014 Net sales for the second quarter of 2014 were a record $206.3 million compared with net sales of $178.1 million for the previous year, an increase of 16%. The majority of the sales increase was driven by sales from recent acquisitions, primarily the units of Specialized, which Alamo acquired in May of this year and to a lesser extent from U.K. based Kellands, acquired in April of this year and two additional Australian acquisitions, Superior and Fieldquip, acquired in September 2013 and April 2014, respectively. A summary including the effects these acquisitions had on the Company's results is included as an attachment to this report. Excluding these acquisitions net sales for the quarter increased 3% to a record $182.7 million. Net income for the second quarter of 2014 was $9.2 million, or $0.75 per diluted share, compared with net income of $11.8 million, or $0.97 per diluted share for the same period of 2013. Excluding the results of the acquired units and related transaction costs and interest, net income for the second quarter was approximately $9.1 million. Net income for the quarter was negatively impacted by significant acquisition-related expenses, accelerated stock option vesting, as well as weaker performance in the Company's North American Agricultural Division primarily due to overall soft agricultural market conditions. For the first six months of 2014, net sales were a record $377.6 million compared with $336.5 million in the previous year, an increase of 12%. Excluding recent acquisitions, net sales for the first six months were a record $353.2 million, an increase of 5%. Net income for the first half of 2014 was $16.4 million or $1.34 per diluted share, versus net income of $18.7 million or $1.54 per diluted share in 2013. Excluding the effects of the previously mentioned acquisitions, net income for the first six months of 2014 was approximately $16.8 million. Sales by Division Alamo Group's North American Industrial Division net sales in the second quarter of 2014 were $105.1 million, an increase of 35% compared with net sales of $77.6 million during the same period of 2013. These results include incremental sales from the Specialized units. During the quarter, the Division continued to benefit from increased demand for its core products in addition to the acquisition of the complementary brands of Specialized. Excluding the Specialized contribution, net sales in the Industrial Division were $86.1 million, an increase of 11% compared with the previous year. For the first six months of 2014, net sales in the Division were $182.4 million versus $147.0 million in 2013, an increase of 24%. Excluding recent acquisitions, net sales were $163.4 million, an increase of 11%. The Company's North American Agricultural Division reported net sales of $52.6 million in the second quarter of 2014, a decrease of 8% compared with net sales of $57.3 million in the previous year. Excluding the effects of the acquisitions of Superior and Fieldquip, both of which are included in this Division's results, net sales were $51.3 million, a decrease of 10%, reflecting generally weaker conditions in the overall U.S. agricultural market. For the first six months of 2014, net sales in the Agricultural Division were $102.5 million compared with 2013 net sales of $106.9 million, a decrease of 4%. Excluding the acquisitions, net sales for the first six months of 2014 were $100.4 million. Net sales in Alamo's European Division for the second quarter of 2014 were $48.6 million, an increase of nearly 13% versus 2013 net sales of $43.2 million. Excluding the Kellands acquisition, net sales for the second quarter rose 5% to $45.4 million. For the first six months of 2014, net sales were $92.7 million or 12% higher compared with $82.6 million in the previous year. Excluding the acquisition, net sales for the first six months of 2014 were $89.4 million, an increase of 8%. These results reflect gradually improving demand for the Company's products in the European sector, further aided by changes in exchange rates. Ron Robinson, Alamo Group's President and Chief Executive Officer, commented, "This was a busy quarter for our Company. It was very gratifying to complete the acquisition of the Specialized business units, though the contributions they made for the partial quarter they were with us were offset by high levels of acquisition-related expenses. Had they been with us for the full quarter all of these costs would have been more than offset. We believe our third quarter results will more fully reflect the benefits this combination will contribute to Alamo going forward as it will include a full quarter's results with no transaction costs. "The results for the quarter were also impacted by higher stock option expenses. The Company normally makes most of its stock based compensation awards in the second quarter of the year and this time these costs were noticeably above average largely related to the accelerated vesting options to retirement eligible recipients. "We were also disappointed by our Agricultural Division's results, which felt the effects of the general slowdown in that sector. These weaker conditions began in mid-2013, and while we managed to still report improved sales into the first quarter of this year, we were unable to sustain that pace in the second quarter. Notwithstanding the market conditions, we did not manage this decline as well as we could have and allowed our margins to slip and inventory to grow. These areas will receive greater focus in the second half of the year. "Our European Division helped offset some of these declines as their results reflect continued improvement in the demand for our agricultural and industrial products in that region overall. However, these conditions vary widely by country and our units based in the U.K. have experienced stronger growth than our French units, which are still being constrained by weaker local economic conditions. "Once again, our North American Industrial Division reported our strongest results as we continue to benefit from steadily improving demand for our broad range of infrastructure maintenance products. The second quarter results from the Division were particularly welcome given the generally weak start we had for the year as a result of adverse weather conditions in the first quarter. We believe we are well positioned to take advantage of any increase in demand for our types of products to support the underserved needs of an aging infrastructure. Our capabilities in this area have been greatly enhanced with the addition of the Specialized business units that include Super Products, Wausau-Everest, HP Fairfield and related entities which should benefit Alamo nicely in the second half of 2014 and for years to come. "While acquisition-related expenses and disappointing declines in our Agricultural Division results more than offset the gains we made in Europe and our Industrial Division in the second quarter of 2014, we continue to be optimistic about the prospects for our Company. Strong performance from our Industrial group, the improving market in Europe, positive long term fundamentals in the agricultural sector and the benefits that are just starting to become evident from our recent acquisitions bode well for the future of Alamo Group. Supporting our optimism is our backlog which ended the second quarter at over $163 million, up 69% from last year at this time and even up 9% when you exclude acquisitions. And, our backlogs are continuing to increase in July with our Agricultural Division units being further aided by the kickoff of their out of season selling programs. This gives us confidence in our ability to perform for the remainder of 2014." Earnings Conference Call Alamo Group will host a conference call to discuss the second quarter results on Thursday, August 7, 2014 at 11:00 a.m. Eastern (10:00 a.m. Central, 9:00 a.m. Mountain and 8:00 a.m. Pacific). Hosting the call will be members of senior management. Individuals wishing to participate in the conference call should dial 888-455-2260 (domestic) or 719-325-2376 (internationally). For interested individuals unable to join the call, a replay will be available until Thursday, August 14, 2014 by dialing 888-203-1112 (domestic) or 719-457-0820 (internationally), passcode 1399099. The live broadcast of Alamo Group Inc.'s quarterly conference call will be available online at the Company's website, www.alamo-group.com (under "Investor Relations/Events & Presentations") on Thursday, August 7, 2014, beginning at 11:00 a.m. ET. The online replay will follow shortly after the call ends and will be archived on the Company's website for 60 days. About Alamo Group Alamo Group is a leader in the design, manufacture, distribution and service of high quality equipment for infrastructure maintenance, agriculture and other applications. Our products include truck and tractor mounted mowing and other vegetation maintenance equipment, street sweepers, snow removal equipment, excavators, vacuum trucks, other industrial equipment, agricultural implements and related after-market parts and services. The Company, founded in 1969, has approximately 3,100 employees and operates 24 plants in North America, Europe and Australia. The corporate offices of Alamo Group Inc.
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Doors open at 5:15 p.m. and the program begins at 6 p.m. General admission is $30. Tickets may be purchased at the Ozark Civic Center or the Dale Medical Center business office. UPCOMING The Wiregrass Decorative Painters Chapter in Enterprise is sponsoring a two-day oil painting seminar taught by artist Bill Bayer on Sept. 12 and 13. The seminar will be held at the First United Methodist Churchs Gathering Room on Chancy Street in Enterprise. The cost is $85 per day and covers all oil paints, brushes and prepped canvases. The seminar is open to the public. Pre-registration is required. Registration deadline forthis seminar is July 15. For questions or to register, contact Joretta Parker at email@example.com or (334) 393-2191 or cell (334) 406-0593. The Wiregrass Master Gardeners Association will hold its Fall Plant Sale on Saturday, Oct. 11, from 9 a.m. to 2 p.m. The sale will be in the Master Gardener nursery located in The Dothan Area Botanical Gardens, 5190 Headland Avenue, Dothan. Fall is the ideal time to plant trees, shrubs, spring-blooming bulbs and perennials. We will have all of those types of plants as well as house plants, succulents and hanging baskets. Each of the plants is lovingly grown by a certified master gardener who is willing to share planting directions and plant care. Admission to the sale is free and it is a great time of year to tour the beautiful Dothan Botanical Gardens. For further information, please contact Cheryl Hatcher at (334) 798-1034 or firstname.lastname@example.org . The Hawkins Travel Group will be going to Biltmore Estate and Ashville, N.C., Nov. 10-13. Reservations need to be made in advance. The tour includes the Biltmore Estate House and Gardens, which will be decorated for Christmas; guided tour of Asheville, N.C.; the magnificent St. Lawrence Basilica; scenic Blue Ridge Parkway; and the famous Folk Art Center. Contact Jacque Hawkins at (334) 470-7095, for additional information. A 10-day Vantage River Cruise, Waterways of Holland and Belgium: Tulips Windmills and Canals is departing April 25, 2015, and requires early registration due to only two months availability. Interested individuals should contact Jacque Hawkins at 470-7095. ONGOING If you like old country and rock music, you can enjoy dancing to it every Friday night from 7 until 10 p.m. at the M.N. Jug Brown Recreation Center on East Lee Street in Enterprise, sponsored by the Boll Weevil Dance Club. Admission is $5 with free refreshments. Also, there will be watermelon served at the 4th of July dance. The Supplemental Nutrition Assistance Program/ Food Stamp Program (SNAP) helps Alabama seniors age 60+ purchase healthy food at the grocery store. You may qualify for food stamps if your income is less than $1,580 per month. If your income is higher and you have costly medical or living expenses, you may still qualify. Call SARCOA at 1-800-239-3507 for assistance in filling out a SNAP application. The National Alliance for Mentally Ill of Coffee County support group meets the first Monday of each month at Johns Chapel A.M.E. Church, 841 Geneva Hwy., from 4:30 to 6:30 p.m. For more information, call Ruthie Warren at 347-1361. The New Life Center, 317 North Main Street, Enterprise, is accepting applications for men and women to enter recovery from drugs and alcohol. For more information, call (334) 393-5641 24 hours a day. The Reunion Committee of the EHS Graduating Class of 1964 is attempting to contact fellow graduates in order to inform them of plans for the Class of 1964 50th Class Reunion, which is scheduled for June 2014. If there are members of the class who have not been contacted, please email the Reunion Committee as soon as possible at email@example.com The Enterprise Senior Center is offering free art classes with Rosa Quattlebaum on Tuesdays from 9 to 11 a.m. and 12:30 to 2:30 p.m. For more information, call Leta Muraski at 347-3513 or email firstname.lastname@example.org . Disabled American Veterans (DAV) Chapter #99 meet each Tuesday and Wednesday from 10 a.m. to noon. Chapter #99 maintains a DAV Service Office in the New Brockton Police Station located at 202 South John Street. This office will assist veterans who were injured or disabled while in military service.
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W. Shrub, will certainly be the featured speaker at the Latino Memphis Management Luncheon Sept. 9. Bush will discuss throughout the first Management Luncheon his ideas on the role Latinos play in the country and will certainly discuss topics including education and learning reform, migration and improved civic and political participation by Latinos. The event will certainly happen at the College of Memphis Holiday Inn, 3700 Central Ave, from 11:30 a.m. to 1 p.m. Medtronic Wins Approval For Cervical Disc Product Medtronic, Inc. has actually gotten authorization from the U.S. Food and Drug Administration to market the Prestige LP Cervical Disc Device for the procedure of single-level cervical disc disease (radiculopathy and/or myelopathy). The Prestige LP Cervical Disc is the 3rd scientifically shown artificial cervical disc in the Medtronic profile and builds on the exact same style concepts as the original Status Cervical Disc introduced in 2007. Rather than using bone screws to affix to the vertebral physical bodies as in the initial Prestige style, the LP style incorporates 2 rails positioned off midline that press-fit into two pre-drilled openings produced during the surgical procedure. Furthermore, the Status LP Disc is made up of a proprietary titanium-ceramic composite that has been shown to have a reduced wear price and produce much less scatter on postoperative magnetic vibration imaging (MRI) compared to stainless steel (MR Conditional at 3 Tesla). Our goal was to keep the very same ball-and-trough articulation as in the initial design, yet to locate a method to lessen the profile and ride a product with enhanced postoperative MRI visualization, claimed Dr. Vincent Traynelis, supervisor of Neurosurgery Back Solutions and vice chairperson and instructor of the Department of Neurosurgery at Rush University Medical Facility in Chicago. To attend to these problems, the Prestige LP Disc incorporates a dual-rail fixation mechanism rather than bone screws and is made from a titanium-ceramic composite rather than stainless steel. The Prestige LP Cervical Disc has actually been offered outside the Usa given that 2004 and has been examined in a prospective, multicenter, historical-controlled U.S. IDE trial for a single-level sign, according to Medtronic. ) For the original version including any additional pictures or video clip, check out ) http://www.memphisdailynews.com/news/2014/aug/2/digest/
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"Tell the chef, the beer is on me."
"Basically the price of a night on the town!"
"I'd love to help kickstart continued development! And 0 EUR/month really does make fiscal sense too... maybe I'll even get a shirt?" (there will be limited edition shirts for two and other goodies for each supporter as soon as we sold the 200)