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Host-directed Therapy: A New Sort Of Tb Procedure

TB remains a major cause of disability and death worldwide as an estimated 8.6 million people fell ill with TB and 1.3 million people died from the disease in 2012, according to the World Health Organization. Although TB is curable, adherence to therapy is difficult as treatment requires taking antibiotic drugs for at least six months and sometimes up to two years. Poor adherence to medication and other factors have resulted in drug-resistant strains, and currently no effective TB vaccine exists. To address the need for alternative interventions, scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, demonstrated proof-of-concept for a host-directed strategy to treat tuberculosis. They found that interleukin-1, a type of protein that regulates the body's immune response to infection, can help protect the body from TB infection. Their studies in cells and in mice and human patients infected with TB bacteria demonstrated that interleukin-1 induces a mediator, prostaglandin E2 (PGE2), that limits the production of type-I interferons, which are associated with increased TB disease severity. The scientists found that host-directed immunotherapy using PGE2 and zileuton, a clinically-approved drug typically used to treat asthma, prevented death in TB-infected mice. This strategy could be of particular benefit to people infected with drug-resistant TB strains who have limited options for effective antibiotics because the treatment increased bacterial control and limited disease even in the absence of TB chemotherapy. In principle, this approach is compatible with standard antibiotic regimens, according to the authors. In future studies, NIAID scientists will test adjunct host-directed therapies in TB-infected individuals. ARTICLE: KD Mayer-Barber et al. Host-directed therapy of tuberculosis based on interleukin-1 - type I interferon crosstalk. Nature. DOI: 10.1038/nature13489 (2014). WHO: NIAID Director Anthony S. Fauci, M.D., is available to comment on this research. Katrin Mayer-Barber, Ph.D., of NIAID's Laboratory of Parasitic Diseases and Alan Sher, Ph.D., chief of the laboratory, are co-authors on the letter and are also available for comment.
For the original version including any supplementary images or video, visit http://www.news-medical.net/news/20140628/Host-directed-therapy-A-new-type-of-TB-treatment.aspx

What Type of Hosting Do You Need For Your Website?

The company that owns the server rents storage space out to individual websites, making their files available to the internet. These servers are maintained and updated by the company, making them great for anyone who does not have the time or knowledge to keep their own server up and running, or to fix it when it goes down. Small businesses usually do not have a dedicated technology support team, and therefore, this is a great option for these kinds of businesses. These shared servers are also a much cheaper option than other hosting solutions. Because lots of website owners pay into the server, the costs are lower overall, plus you have the added benefit of server specialists, who know how to make sure your website is running at peak performance. Experts warn however, that while shared hosting may be a good option for some, it may not be the best option for everyone. Massive sites that get a lot of traffic need more space for storage and more bandwidth than other websites that might run just fine on less dedicated servers. Related Resources from B2C Free Webcast: The Art of Agile Marketing: How Geek Theory Helped Creative Teams Increase Productivity Dedicated Hosting Dedicated hosting is a server dedicated entirely to your website. Like it says above, this is a great option for those who have the manpower and resources to keep this server running, as, when you own your own server, you need to be able to repair it when it breaks and give it technological support when it goes down. Large corporations, or even small businesses with a great tech-minded team can spring for and manage one, especially if they are expecting a huge amount of traffic on their website, or if the website needs to contain massive amounts of information, videos, or pictures. Plus, you have full control over who uses or tampers with your server and website. Youll never wake up one morning and find that you no longer have a webpage because your spot on the server has disappeared. You also have the ability to pay someone else to keep and maintain a server that is still entirely dedicated to your website. If your business does not have the expertise to build a website, much less maintain a server, dedicated hosting might not be the best choice. In shared hosting, you have a team of experts to administer to your server and website whenever you need help. With dedicated hosting, you are that team, and keeping your server running at the level you want can be difficult. Virtual Private Hosting In between shared hosting and dedicated hosting is virtual private hosting. In this option, you and a group of other website owners share a private server.
For the original version including any supplementary images or video, visit http://www.business2community.com/online-marketing/type-hosting-need-website-0643810

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